HAN-P-20
Ja-Hyoung Ryu
UNIST
Professor
South Korea
Peptide Assembly, Nanomedicine, Supramolecular Chemistry
Academic Career
B.S., 2000, Yonsei University; Ph.D., 2006, Yonsei University (advisor: Myongsoo Lee); Postdoctoral Training, 2007-2011, University of Massachusetts Amherst (advisor: S. Thayumanavan); Assistant Professor, 2012-2016, Ulsan National Institute of Science and Technology; Associate Professor (Tenured), 2017-2022, Ulsan National Institute of Science and Technology; Professor, 2023-present, Ulsan National Institute of Science and Technology
Selected Publications
Supramolecular Senolytics, Kim, S., et al., J. Am. Chem. Soc. 145, 21991-22008 (2023)
Intra-Lysosomal Peptide Assembly. Jana, B., et al., J. Am. Chem. Soc. 145, 18414-18431 (2023)
Cancer-Selective Supramolecular Chemotherapy., Jeena, M.T., et al., Adv. Funct. Mater, 32, 2208098 (2022)
Intramitochondrial Co-assembly between ATP and Nucleopeptide. Choi, H., et al., Chem. Sci. 13, 6197(2022)
Stimuli-Responsive Adaptive Nanotoxin. Jeong, Y., et al., J.Am. Chem. Soc. 144, 5503 (2022)
Intramitochondrial Disulfide Polymerization. Kim, S., et al., ACS Nano 15, 14492 (2021)
Why My Lab?
The research theme of the Ryu research group is the development of new disease therapy using supramolecular approach (Supramolecular Therapeutics). The Ryu group have developed the conventional-drug-free approach for a new anti-cancer/anti-ageing therapy, that intracellular (supramolecular) polymerization inside the mitochondria induced the dysfunction of mitochondria by disrupting the membrane, resulting in the selective apoptosis of cancer/senescent cells.
